The Lower East Side is, of course, in the southeast portion of Manhattan, along the East River near where multiple bridges and tunnels connect Manhattan with Brooklyn.
Please make sure you read your reservation's cancellation policy!
You'll be given this information with the available room rates after you select a hotel and specify dates. Many hotels have cancellation penalties associated with their best rates. Most offer "Book Now and Pay Later" options that are less restrictive, but slightly more expensive.